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Peripheral blood indicators and COVID-19: an observational and bidirectional Mendelian randomization study.
- Source :
- BMC Medical Genomics; 3/28/2024, Vol. 17 Issue 1, p1-12, 12p
- Publication Year :
- 2024
-
Abstract
- Blood is critical for health, supporting key functions like immunity and oxygen transport. While studies have found links between common blood clinical indicators and COVID-19, they cannot provide causal inference due to residual confounding and reverse causality. To identify indicators affecting COVID-19, we analyzed clinical data (n = 2,293, aged 18–65 years) from Guangzhou Medical University's first affiliated hospital (2022-present), identifying 34 significant indicators differentiating COVID-19 patients from healthy controls. Utilizing bidirectional Mendelian randomization analyses, integrating data from over 2.46 million participants from various large-scale studies, we established causal links for six blood indicators with COVID-19 risk, five of which is consistent with our observational findings. Specifically, elevated Troponin I and Platelet Distribution Width levels are linked with increased COVID-19 susceptibility, whereas higher Hematocrit, Hemoglobin, and Neutrophil counts confer a protective effect. Reverse MR analysis confirmed four blood biomarkers influenced by COVID-19, aligning with our observational data for three of them. Notably, COVID-19 exhibited a positive causal relationship with Troponin I (Tnl) and Serum Amyloid Protein A, while a negative association was observed with Plateletcrit. These findings may help identify high-risk individuals and provide further direction on the management of COVID‐19. [ABSTRACT FROM AUTHOR]
- Subjects :
- COVID-19
TROPONIN I
BLOOD proteins
CAUSAL inference
Subjects
Details
- Language :
- English
- ISSN :
- 17558794
- Volume :
- 17
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Medical Genomics
- Publication Type :
- Academic Journal
- Accession number :
- 176339873
- Full Text :
- https://doi.org/10.1186/s12920-024-01844-4