Back to Search Start Over

Thymus Surgery Prospectives and Perspectives in Myasthenia Gravis.

Authors :
Salahoru, Paul
Grigorescu, Cristina
Hinganu, Marius Valeriu
Lunguleac, Tiberiu
Halip, Alina Ioana
Hinganu, Delia
Source :
Journal of Personalized Medicine; Mar2024, Vol. 14 Issue 3, p241, 16p
Publication Year :
2024

Abstract

The thymus is a lymphoid organ involved in the differentiation of T cells, and has a central role in the physiopathogenesis of Myasthenia Gravis (MG). This connection is proved by a series of changes in the level of neuromuscular junctions, which leads to a decrease in the amplitude of the action potential in the post-synaptic membrane. Because of this, the presence of anti-cholinergic receptor antibodies (AChR), characteristic of MG, is found, which causes the progressive regression of the effect of acetylcholine at the level of neuromuscular junctions, with the appearance of muscle weakness. The thymectomy is a surgical variant of drug therapy administered to patients with MG. In the case of patients with nonthymomatous MG, thymectomy has become a therapeutic standard, despite the fact that there is no solid scientific evidence to explain its positive effect. Videothoracoscopic surgery or robotic surgery led to a decrease in the length of hospital stay for these patients. This paper aims to synthesize the information presented in the literature in order to create a background for the perspectives of thymectomy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20754426
Volume :
14
Issue :
3
Database :
Complementary Index
Journal :
Journal of Personalized Medicine
Publication Type :
Academic Journal
Accession number :
176334364
Full Text :
https://doi.org/10.3390/jpm14030241