New Ischemia Study Findings Have Been Published by Researchers at Weill Cornell Medicine (Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases).

A new report from Weill Cornell Medicine presents fresh data on ischemia, a condition caused by reduced blood flow to tissues. The researchers used a proteomics approach to identify proteins that undergo ubiquitination, a process that alters protein function and stability, in mice with ischemic stroke. They found increased ubiquitination of 198 proteins, many of which are located in the postsynaptic density (PSD) of glutamatergic neurons. The study also revealed altered kinase activities and phosphorylation patterns in the PSD following stroke. The findings suggest that ubiquitination plays a role in regulating essential kinases involved in ischemic injury. [Extracted from the article]