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Diagnosing Cutaneous Melanocytic Tumors in the Molecular Era: Updates and Review of Literature.

Authors :
Huang, Chelsea
Lau, Tiffany Wing-See
Smoller, Bruce R.
Source :
Dermatopathology; Mar2024, Vol. 11 Issue 1, p26-51, 26p
Publication Year :
2024

Abstract

Over the past decade, molecular and genomic discoveries have experienced unprecedented growth, fundamentally reshaping our comprehension of melanocytic tumors. This review comprises three main sections. The first part gives an overview of the current genomic landscape of cutaneous melanocytic tumors. The second part provides an update on the associated molecular tests and immunohistochemical stains that are helpful for diagnostic purposes. The third section briefly outlines the diverse molecular pathways now utilized for the classification of cutaneous melanomas. The primary goal of this review is to provide a succinct overview of the molecular pathways involved in melanocytic tumors and demonstrate their practical integration into the realm of diagnostic aids. As the molecular and genomic knowledge base continues to expand, this review hopes to serve as a valuable resource for healthcare professionals, offering insight into the evolving molecular landscape of cutaneous melanocytic tumors and its implications for patient care. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22963529
Volume :
11
Issue :
1
Database :
Complementary Index
Journal :
Dermatopathology
Publication Type :
Academic Journal
Accession number :
176298060
Full Text :
https://doi.org/10.3390/dermatopathology11010005