Evaluation of the diagnostic value of total bile acids/platelets in HBV related liver fibrosis.

Objective: Explore the diagnostic value of total bile acids/platelets in HBV related liver fibrosis. Methods: 160 patients with chronic HBV infection admitted to the Infection Department of the First Affiliated Hospital of Hainan Medical College from February 2021 to December 2022 were selected. They were divided into two groups based on the degree of liver fibrosis detected by liver biopsy: significant liver fibrosis group and non-significant liver fibrosis group. The total bile acid/blood platelet levels and their correlation with liver fibrosis in the two groups were compared and observed, and the efficacy of other non-invasive liver fibrosis diagnostic models was evaluated. Results: (1) Compared with the non-significant liver fibrosis group, the significant liver fibrosis group showed an increase in total bile acid levels, a decrease in platelet levels, and a significant increase in total bile acid/platelet levels (P<0.05). (2) Platelets decrease with the increase of liver fibrosis degree, total bile acids increase with the increase of liver fibrosis degree, and total bile acids/platelets increase with the increase of liver fibrosis degree. (3) The area under the curve (AUC) of total bile acid/platelet, APRI, FIB-4, and elastography in diagnosing the degree of liver fibrosis were 0.69, 0.57, 0.56, and 0.68, respectively. Conclusions: The diagnostic efficacy of total bile acids/platelets in diagnosing HBV related liver fibrosis is no less than that of other liver fibrosis diagnostic methods, and it is non-invasive, simple, and convenient, which is worthy of further clinical promotion and validation. [ABSTRACT FROM AUTHOR]