新たな非侵襲末梢血管状態評価への応用を目的としたウインド ケッセルモデルパラメータ算出に用いる脈波計測手法の検討.

A novel diagnostic method has been developed for microvascular lesions using time constants obtained from the peripheral Windkessel model (WK model). Since the time constant of the WK model reflects changes in resistance and vascular elasticity due to a decrease in the internal vessel diameter, an increase in surface roughness of intima, andan increase in bloodviscosity, it was proposedto use it as an indicator for vascular evaluation. For noninvasive andeasy measurement of the time constant, it is necessary to calculate from the frequency components of the arterial pressure pulse andphalangeal volume pulse. Therefore, it is necessary to establish each pulse wave measurement methodandto consider the optimal combination. The fingertip photoplethysmograph was usedbecause it is saidto be proportional to the volume pulse of the fingertip. Owing to the difficulty of using the conventional air-conduction method for measuring the arterial pressure pulse, reflection photo and cuff pressure methods were considered. The probability of obtaining time constants and the fluctuation rate were compared across the three methods. The results demonstrated the superiority of the air-conduction methodover the other two. The air-conduction methodwas consideredto produce a waveform proportional to the arterial bloodpressure pulse wave. The best pulse wave measurement methodfor measuring peripheral time constants were the air-conduction methodfor arterial pressure pulse andthe transmission photo methodfor fingertip volume pulse. [ABSTRACT FROM AUTHOR]