Single‐cell sequencing reveals alterations in the peripheral blood mononuclear cell landscape and monocyte status during colorectal adenocarcinoma formation.

This article discusses a study that investigated non-invasive methods for early detection of colorectal cancer (CRC) and alternatives to colonoscopy. The researchers used single-cell RNA sequencing to analyze immune cells in the blood of healthy individuals, colon adenoma patients, and colon adenocarcinoma patients. They observed changes in cell types and interactions during CRC development and identified different monocyte states and gene expression patterns associated with CRC progression. The study suggests that certain genes may serve as potential diagnostic biomarkers for colorectal cancer, but more research is needed to validate these findings. [Extracted from the article]