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BRCA mutation in Vietnamese prostate cancer patients: a mixed cross-sectional study and case series.

Authors :
Cam Pham, Phuong
Van Pham, Thai
Doan Dinh, Long
Thuan Nguyen, Loi
Viet Le, Nam
Bich Bui, Mai
Quang Nguyen, Hung
Van Pham, Tuyen
Thuy Thi Vo, Quynh
Binh Vu, Thu
Thu Thi Vu, Hien
Bich Thi Le, Ngoc
Quoc Hoang, Binh
Lan Thi Luong, Anh
Thi Nguyen, Hoai
Phuong Thi Nguyen, Ly
Minh Pham, Lanh
Phuong Ngo, Thuy
Minh Nguyen, Hien
Ngoc Tran, Dang
Source :
Oncologie (De Gruyter); Mar2024, Vol. 26 Issue 2, p247-256, 10p
Publication Year :
2024

Abstract

Prostate cancer features have been linked to mutations in the BRCA1 and BRCA2 genes. Assessing the status of BRCA1 and BRCA2 gene carriers in patients contributes to accurate diagnosis, disease prognosis as well as appropriate targeted treatment methods. This study evaluated the prevalence of these mutations in Vietnamese prostate cancer patients and assessed their correlation with clinical features. A cross-sectional study was performed at Bach Mai Hospital between 2021 and 2022. We enrolled 60 prostate cancer patients. Next-generation gene sequencing was used to identify BRCA1 and BRCA2 mutations in formalin-fixed paraffin-embedded samples. Patients with somatic gene mutations underwent further germline mutation analysis. We also reported a case series following the British Medical Journal guidelines, detailing the clinical course of such patients. Patients with BRCA2 pathogenic variants revealed no BRCA1 mutations, although different mutations were identified. Two patients showed germline mutations. Patients with BRCA mutations were younger (average age: 66.2 years) than those with non-mutations (72.1 years) at diagnosis. High Gleason scores, lymph node metastases, and distant metastases were more prevalent in the mutation group. One patient with germline BRCA mutation had aggressive prostate cancer and early resistance to non-PARPi (Poly ADP-ribose polymerase inhibitors) treatments. We provide preliminary data on BRCA mutations in Vietnamese patients with prostate cancer, suggesting that BRCA2 mutations correlate with aggressive disease characteristics. Our findings further elucidate the clinical implications of these mutations. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
12923818
Volume :
26
Issue :
2
Database :
Complementary Index
Journal :
Oncologie (De Gruyter)
Publication Type :
Academic Journal
Accession number :
176194449
Full Text :
https://doi.org/10.1515/oncologie-2023-0556