New Breast Cancer Study Results from Chongqing Medical University Described (Oxidized Atm Governs Stemness of Breast Cancer Stem Cell Through Regulating Ubiquitylation and Acetylation Switch).

A study conducted by researchers at Chongqing Medical University in China explores the mechanisms by which cancer stem cells (CSCs) maintain their stemness in triple-negative breast cancer cells. The study reveals that oxidized ATM, a hypoxia-activated cytoplasm ATM, plays a role in maintaining CSC stemness by regulating histone H4 acetylation. The researchers found that oxidized ATM phosphorylates TRIM21, leading to the ubiquitination-mediated degradation of SIRT1 and an increase in histone H4 acetylation. Clinical data also showed a positive correlation between high levels of ATM in breast tumors and malignant grade. This study provides new insights into the regulation of CSCs and their maintenance in breast cancer. [Extracted from the article]