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Endoscopic papillectomy could be rewarding to patients with early stage duodenal ampullary carcinoma?

Endoscopic papillectomy could be rewarding to patients with early stage duodenal ampullary carcinoma?

Authors :
Suzuki, Ko
Kurita, Yusuke
Kubota, Kensuke
Fujita, Yuji
Tsujino, Seitaro
Koyama, Yuji
Tsujikawa, Shintaro
Tamura, Shigeki
Yagi, Shin
Hasegawa, Sho
Sato, Takamitsu
Hosono, Kunihiro
Kobayashi, Noritoshi
Iwashita, Hiromichi
Yamanaka, Shoji
Fujii, Satoshi
Endo, Itaru
Nakajima, Atsushi
Source :
Journal of Hepato -- Biliary -- Pancreatic Sciences; Mar2024, Vol. 31 Issue 3, p203-212, 10p
Publication Year :
2024

Abstract

Background/Purpose: There is currently no consensus on the use of endoscopic papillectomy (EP) for early stage duodenal ampullary adenocarcinoma. This study aimed to evaluate the feasibility of EP for patients with early stage duodenal ampullary adenocarcinoma. Methods: Patients who underwent EP for ampullary adenocarcinomas were investigated. Complete and clinical complete resection rates were evaluated. Clinical complete resection was defined as either complete resection or resection with positive or unknown margins but no cancer in the surgically resected specimen, or no recurrence on endoscopy after at least a 1‐year follow‐up. Results: Adenocarcinoma developed in 30 patients (carcinoma in situ [Tis]: 21, mucosal tumors [T1a(M)]: 4, tumors in the sphincter of Oddi [T1a(OD)]: 5). The complete resection rate was 60.0% (18/30) (Tis: 66.7% [14/21], T1a[M]: 50.0% [2/4], and T1a[OD]: 40.0% [2/5]). The mean follow‐up period was 46.8 months. The recurrence rate for all patients was 6.7% (2/30). The clinical complete resection rates of adenocarcinoma were 89.2% (25/28); rates for Tis, T1a(M), and T1a(OD) were 89.4% (17/19), 100% (4/4), and 80% (4/5), respectively. Conclusions: EP may potentially achieve clinical complete resection of early stage (Tis and T1a) duodenal ampullary adenocarcinomas. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18686974
Volume :
31
Issue :
3
Database :
Complementary Index
Journal :
Journal of Hepato -- Biliary -- Pancreatic Sciences
Publication Type :
Academic Journal
Accession number :
176118533
Full Text :
https://doi.org/10.1002/jhbp.1398