Effects of endodontic irrigation solutions on structural, chemical, and mechanical properties of coronal dentin: A scoping review.

Objective: This review aims to assess structural, chemical, and mechanical properties of coronal dentin after endodontic irrigation. Materials and Methods: Reporting followed the PRISMA extension for scoping reviews. An electronic search was carried out in PubMed, Embase, and Cochrane Library. Records filtered by language and published up to November 4, 2022 were independently screened by two researchers. Studies evaluating structural, chemical, or mechanical properties of human permanent coronal dentin after irrigation within the scope of nonsurgical root canal treatment were included. Data were extracted regarding study type, sample description and size, experimental groups, outcome, evaluation method, and main findings. Results: From the initial 1916 studies, and by adding 2 cross‐references, 11 in vitro studies were included. Seven studies provide ultrastructural and/or chemical characterization, and six assessed microhardness and/or flexural strength. One percent to 8% sodium hypochlorite (NaOCl) and 1%–17% ethylenediaminetetraacetic acid (EDTA) were the most commonly tested solutions, with contact times of 2–240 min (NaOCl) and 1–1440 min (EDTA) being evaluated. Conclusions: Overall, the literature is consensual regarding the inevitable impact of NaOCl and chelating agents on coronal dentin, with both deproteinizing and decalcifying effects being concentration‐ and time‐dependent. The alteration of mechanical parameters further confirmed the surface and subsurface ultrastructural and chemical changes. Clinical Significance: Endodontic treatment success highly depends on restorative sealing. Understanding the result of exposing coronal dentin, the main substrate for bonding, to irrigants' action is crucial. The deproteinizing and decalcifying effects of NaOCl and chelating agents are both concentration‐ and time‐dependent, causing surface and subsurface ultrastructural, chemical, and mechanical alterations. [ABSTRACT FROM AUTHOR]