Part I: Case series: Acute management of prescription and nonprescription drug overdoses.

This document is a part of the Pharmacotherapy Self-Assessment Program (PSAP) and provides information on the acute management of prescription and nonprescription drug overdoses. It emphasizes the importance of supportive care, exposure history, and understanding toxidromes in guiding treatment decisions. The article discusses the treatment paradigm in toxicology, including decontamination methods, enhanced elimination techniques, and focused antidotes. It recommends consulting toxicologists or poison centers for guidance in managing drug overdoses and highlights the value of involving poison centers and toxicologists in patient care. The document also provides information on the management and treatment of specific drug overdoses, such as Type 1 antiarrhythmics, diphenhydramine, bupropion, digoxin, and various toxic substances. It covers symptoms, treatment options, and the importance of early toxicologist involvement. Additionally, the document presents clinical cases to guide healthcare professionals in making appropriate treatment decisions. [Extracted from the article]