Fibroblasts as an in vitro model of circadian genetic and genomic studies (Updated March 5, 2024).

This article discusses a study that examines the genetic architecture of circadian rhythm in fibroblasts, a type of connective tissue cell. The researchers collected temporal genomic data from healthy individuals and found that only a limited number of genes displayed consistent circadian patterns of expression. They also identified transcription factor families associated with regions that were increasing or decreasing in accessibility over time. However, further analysis did not find a significant presence of these regions in the known genetic architecture of bipolar disorder or other psychiatric disorders. The study highlights the biological pathways activated in this in vitro circadian model and discusses its limitations and future applications for circadian genomic studies. [Extracted from the article]