Studies from Jiangnan University in the Area of Treponema pallidum Reported (Regulation of Chemotactic Effects On Brain Vascular Endothelial Cells By the Targeted Chemokine Receptor Signaling Pathway of Treponema Pallidum).

A study conducted by researchers at Jiangnan University in Jiangsu, China, explores the regulatory mechanisms of Treponema pallidum, the bacterium that causes syphilis, on chemokine receptors in human brain microvascular endothelial cells (HBMEC). The study found that exposure to active Treponema pallidum increased the expression of chemokines CXCL7 and CXCL13 in HBMEC, promoting chemotaxis and enhancing the migratory potential of HL-60 cells. Neurosyphilis patients also exhibited elevated serum levels of CXCL7 and CXCL13 compared to healthy controls. The researchers suggest that these interactions may play a role in the pathogenesis of neurosyphilis. Further studies are recommended to investigate more complex blood-brain barrier models and assess the capabilities of migrated cells. [Extracted from the article]