Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes.

In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-N-phenyl-1H-pyrazole-3-carboxamide (L₁) and 1,5-dimethyl-N-propyl-1H-pyrazole-3-carboxamide (L₂), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni(L₁)₂](ClO₄)₂ (C₁) and a dinuclear complex [Cd₂(L₂)₂]Cl₄ (C₂). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, L₁ and L₂ present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes C₁ and C₂. [ABSTRACT FROM AUTHOR]