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Association of Low Vitamin D and Intact Parathyroid Hormone (iPTH) in Nepalese Population: When Does iPTH Exactly Rise?
- Source :
- Journal of the Endocrine Society; Apr2024, Vol. 8 Issue 4, p1-5, 5p
- Publication Year :
- 2024
-
Abstract
- Vitamin D deficiency is a global public health concern that provokes bone demineralization and weakening. In response to the decreased vitamin D level, calcium stores wear out. The homeostatic effect of compensatory hyperparathyroidism in vitamin D deficiency incites variable discrepancies in different populations. This study intends to decipher the transition point of PTH in relation to levels of vitamin D in a Nepalese population. A cross-sectional study was carried out at Tribhuvan University Teaching Hospital, Nepal. Serum calcium, phosphorus, intact PTH, and 25-hydroxy vitamin D levels were assayed in an Abbott ARCHITECT Integrated System. A correlation plot of PTH and vitamin D was analyzed in Statistical Package for Social Sciences version 22.0. Using a locally weighted scatter plot smoothing method, the relation between these variables was presented graphically. Among 281 individuals, 30.2% had vitamin D levels below 20 ng/mL. There was an archetypical transition in the PTH levels in concert with the decrease in vitamin D level marked by 2 inflection points (ie, 18.5 and 42.0 ng/mL). Our findings suggest that to augment overall health and avert weakness due to vitamin D deficiency, the levels of vitamin D should be maintained above 42.0 ng/mL in our population. [ABSTRACT FROM AUTHOR]
- Subjects :
- VITAMIN D
PARATHYROID hormone
VITAMIN D deficiency
NEPALI people
Subjects
Details
- Language :
- English
- ISSN :
- 24721972
- Volume :
- 8
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of the Endocrine Society
- Publication Type :
- Academic Journal
- Accession number :
- 175957869
- Full Text :
- https://doi.org/10.1210/jendso/bvad143