Title of presented paper: Clinical applications of metabolomics.

Introduction and aim. One of the most dynamically developing scientific field is the detection of physicochemical properties of metabolites of the human body. Researchers currently focus on metabolome analysis due to the possibility of targeted therapies for various conditions where changes in metabolism concern not only the levels of single metabolites but quantitative relationships between the levels of small molecule compounds making up a whole metabolic profile. The aim of this research was to summarize the latest findings in the field of metabolomics and its applications in clinical medicine. Material and methods. The review was performed according to the up to date literature. Thorough analysis of the scientific data from PubMed database has been conducted. Analysis of literature. One groundbreaking study determined the metabolic profile of patients qualified for transcatheter aortic valve implantation (TAVI). Acute kidney injury (AKI) is a fairly common complication after TAVI and is associated with a significant increase in mortality. It has been proved that in an elderly population undergoing TAVI, metabolite profiling improves the prediction of AKI and may allow for its prevention by physicians. Metabolomics has also allowed for early detection of biochemical changes associated with the risk of type 2 diabetes. Amino acids such as isoleucine, leucine and valine turned out to be predictive markers of this condition. In multiple myeloma (MM), metabolomics is used to detect biomarkers that confirm the presence of MM and to assess disease progression. Carnitine and acetylcarnitine seem to be significant biomarkers - their concentration in the blood correlates with the stage of neoplastic disease. Increase in carnitine concentration can lead to increase in lipid oxidation in particularly metabolically active myeloma cells. This finding led to the insight that people suffering MM should avoid carnitine supplementation (dairy products, meat). It has been suggested that research into metabolism may also extend human life. So far, specific lipid compounds such as phosphatidylcholine and sphingomyelin have been identified as novel biomarkers of longevity. Conclusion. Metabolomics is an important tool which may provide valuable data used in diagnosis and monitoring of therapy in nearly every field of medicine. However, due to the complexity of human metabolism further studies and research are necessary. [ABSTRACT FROM AUTHOR]