Title of presented paper: The role of aquaporin 4 in the pathogenesis and therapy of Alzheimer's disease.

Introduction and aim. Aquaporin 4 (AQP4) is a major water channel in the central nervous system (CNS). Its expression occurs mainly in astrocytes, although it is also found in ependymocytes lining the ventricles and retina. The main roles played by AQP4 are the uptake of cerebrospinal fluid, participation in the migration of astrocytes to sites of injury and in the removal of toxic protein aggregates. It has been suggested that AQP4 may play an important role in AD. Material and methods. This paper contains a literature review of articles published on Pubmed, Google Scholar scientific databases on the topics of Alzheimer's disease and aquaporin 4. Analysis of literature. Recent studies have shown that AQP4 is involved in clearing the brain of accumulating β-amyloid -- a diagnostic marker for Alzheimer's disease and a major component of so-called "senile deposits". In addition, AQP4 may affect the transport of potassium and calcium ions, which may play a critical role in the pathogenesis of AD. AQP4 also plays important roles in brain plasticity. Moreover, AQP4 knockout is involved in neuroinflammation and impairs the course of AD. Moreover, a correlation has been shown between age, sleep deprivation and AQP4 dysfunction and increased AD risk. Conclusion. Research is underway to develop specific therapeutic agents that would inhibit or enhance AQP4 which is a promising therapeutic target in AD patients. The purpose of this study is to outline the role of AQP4 in the pathogenesis of AD and major depressive disorders, identify risk factors, prevention of these conditions, and hope for new therapies. [ABSTRACT FROM AUTHOR]