Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brain.

A recent study used long-read sequencing to examine the RNA isoform repertoire of neuropsychiatric risk genes in the human brain. The researchers found that these risk genes are more complex than previously thought, identifying 440 novel isoforms and 28 novel exons. They also discovered isoforms that alter protein domains and uncovered previously undiscovered isoforms in genes such as ATG13 and GATAD2A. The study highlights the presence of previously undetected RNA and protein isoforms in the brain and provides a new approach to understanding the functional impact of these isoforms on neuropsychiatric disorders. However, it is important to note that this research has not yet undergone peer review. [Extracted from the article]