New Tissue Engineering Findings Reported from Sun Yat-sen University (Iron Deficiency-induced Ferritinophagy Impairs Skeletal Muscle Regeneration Through Rnf20-mediated H2bub1 Modification).

A recent study conducted at Sun Yat-sen University in Shenzhen, China, has found that iron deficiency (ID) can impair skeletal muscle regeneration. The study focused on ferritinophagy, a type of selective autophagy activated by ID, and its effects on myogenic differentiation. The researchers discovered that ferritinophagy led to the degradation of RNF20, which negatively regulated histone H2B monoubiquitination and inhibited muscle regeneration. The study suggests that the ferritinophagy-RNF20-H2Bub1 axis could be a potential therapeutic target for ID-induced skeletal muscle impairment. [Extracted from the article]