梅毒螺旋体与母胎界面细胞相互作用影响妊娠 结局的机制研究进展.

Treponema pallidum(Tp), a common sexually transmitted pathogen, can infect the fetus via placental vertical transmission, leading to congenital syphilis(CS). This infection results in adverse pregnancy outcomes, such as stillbirth, miscarriage, preterm birth, and fetal growth restriction. However, the exact pathogenesis remains unclear. Studies indicate that patients with early syphilis primarily exhibit pro-inflammatory immune responses. The Tp has been proven to induce dysfunction in various immune cells and abnormal expression of cytokines, potentially disrupting immune tolerance homeostasis and leading to adverse pregnancy outcomes. Grounded in the current understanding of CS and maternal-fetal immunology by scholars both domestically and internationally, this paper provides a comprehensive review of the potential mechanisms of Tp interacting with the cells of the maternal-fetal interface, ultimately leading to adverse pregnancy outcomes. It summarizes the pathogenesis characteristics, clinical manifestations, and maternal-fetal immune responses of CS. [ABSTRACT FROM AUTHOR]