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Cardiovascular risk of dietary trimethylamine oxide precursors and the therapeutic potential of resveratrol and its derivatives.

Cardiovascular risk of dietary trimethylamine oxide precursors and the therapeutic potential of resveratrol and its derivatives.

Authors :
Hou, Chih‐Yao
Chen, Yu‐Wei
Hazeena, Sulfath Hakkim
Tain, You‐Lin
Hsieh, Chang‐Wei
Chen, De‐Quan
Liu, Rou‐Yun
Shih, Ming‐Kuei
Source :
FEBS Open Bio; Mar2024, Vol. 14 Issue 3, p358-379, 22p
Publication Year :
2024

Abstract

Overall diet, lifestyle choices, genetic predisposition, and other underlying health conditions may contribute to higher trimethylamine N‐oxide (TMAO) levels and increased cardiovascular risk. This review explores the potential therapeutic ability of RSV to protect against cardiovascular diseases (CVD) and affect TMAO levels. This review considers recent studies on the association of TMAO with CVD. It also examines the sources, mechanisms, and metabolism of TMAO along with TMAO‐induced cardiovascular events. Plant polyphenolic compounds, including resveratrol (RSV), and their cardioprotective mechanism of regulating TMAO levels and modifying gut microbiota are also discussed here. RSV's salient features and bioactive properties in reducing CVD have been evaluated. The close relationship between TMAO and CVD is clearly understood from currently available data, making it a potent biomarker for CVD. Precise investigation, including clinical trials, must be performed to understand RSV's mechanism, dose, effects, and derivatives as a cardioprotectant agent. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22115463
Volume :
14
Issue :
3
Database :
Complementary Index
Journal :
FEBS Open Bio
Publication Type :
Academic Journal
Accession number :
175826771
Full Text :
https://doi.org/10.1002/2211-5463.13762