Patent Issued for Increasing capture efficiency of spatial assays (USPTO 11898205).

A patent has been issued to 10X Genomics Inc. for a method of increasing the capture efficiency of spatial assays. The patent describes various methods involving the use of capture probes, padlock probes, and oligonucleotides to prepare a spatial array and amplify the capture domain. These methods aim to provide more comprehensive data on spatial heterogeneity within tissues, allowing for the localization and profiling of analytes such as RNA molecules and proteins. The patent also mentions the use of rolling circle amplification and sequencing techniques in conjunction with the spatial array. [Extracted from the article]