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Current usage of long-acting insulin analogs in patients with type 2 diabetes mellitus.
- Source :
- Expert Review of Endocrinology & Metabolism; Mar2024, Vol. 19 Issue 2, p155-161, 7p
- Publication Year :
- 2024
-
Abstract
- Insulin treatment is fundamental to diabetes management. Basal insulin therapy reduces intraday glycemic fluctuations upon reaching a steady state. Besides better blood glucose regulation and achieving target HbA1c values in patients, it also offers protection from diabetes complications. In this review, we aimed to compare basal-acting insulins in light of the literature. We reviewed current evidence related to diabetes treatment with basal insulins. This includes discussions on clinical trials and meta-analyses concerning first and second-generation ultra-long-acting basal insulins. Treatment indications for long-acting basal insulins, which have shown benefits and are considered superior or comparable to others in the literature, are derived from current clinical studies and meta-analyses, which form the basis of the recommendations in this review. First and second-generation basal insulins do not show much superiority over each other in terms of blood glucose regulation and reaching the target HbA1c. However, second-generation basal insulins cause fewer hypoglycemic events. We recommend using the appropriate basal insulin in patient-based, individualized treatments. Basal insulin Icodec may become more widely used over time, owing to its association with less hypoglycemia and a reduction in the number of injections. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17446651
- Volume :
- 19
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Expert Review of Endocrinology & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 175722138
- Full Text :
- https://doi.org/10.1080/17446651.2024.2320631