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Tocilizumab Failed to Reduce Mortality in Severe COVID-19 Patients: Results from a Randomized Controlled Clinical Trial.
- Source :
- Iranian Journal of Allergy, Asthma & Immunology; Feb2024, Vol. 23 Issue 1, p82-96, 15p
- Publication Year :
- 2024
-
Abstract
- The severe coronavirus disease 2019 (COVID-19) is associated with increased levels of blood interleukin (IL)-6. Therefore, it is hypothesized that modulating the levels or effects of IL-6 could diminish airway inflammation and alter the course of COVID-19. We conducted a controlled, randomized, double-blind clinical trial on hospitalized patients with severe COVID-19 in Iran. The patients were randomly distributed by block randomization to take either standard-of-care (SOC) plus 1 or 2 doses of tocilizumab 8 mg/kg or SOC alone. The endpoint was defined by clinical improvement and discharge. We enrolled 40 patients (20 patients in each group) from 10 July to 10 December 2020. After randomization, 1 patient in the SOC arm and 3 patients in the tocilizumab arm refused to participate and were eliminated from the study. The mean age of participants was 59.62±15.80 in the tocilizumab group (8 women and 9 men) and 63.52±12.83 years old in the SOC group (9 women and 10 men) groups. The number of patients who recovered did not differ significantly between the tocilizumab and SOC groups (12 [70.6%][70.6%] vs. 15 [78.9%]), respectively). Hospitalization rates were also similar between the groups (Log-rank test, p=0.615; hazard ratio, 0.83; 95% CI [0.39–1.78]). The results show that tocilizumab could not be a beneficial agent for treating severe cases of COVID-19 patients and would not significantly improve clinical outcomes. [ABSTRACT FROM AUTHOR]
- Subjects :
- COVID-19
CLINICAL trials
RANDOMIZED controlled trials
TOCILIZUMAB
COVID-19 pandemic
Subjects
Details
- Language :
- English
- ISSN :
- 17351502
- Volume :
- 23
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Iranian Journal of Allergy, Asthma & Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 175708481
- Full Text :
- https://doi.org/10.18502/ijaai.v23i1.14956