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Fabrication of GSH‐Responsive Poly(Tertiary Amine‐Oxide)‐Based Nanomedicines for Enhanced Anticancer Drug Release.

Authors :
Zhang, Xianshuo
Ma, Wei
Wang, Peipei
Hou, Shuo
Niu, Wenxu
Shi, Yunfeng
Kang, Guiying
Yu, Cui‐Yun
Wei, Hua
Source :
Macromolecular Chemistry & Physics; Feb2024, Vol. 225 Issue 4, p1-9, 9p
Publication Year :
2024

Abstract

Poly(tertiary amine‐oxide)‐based polymeric nanocarriers have showed more functionalities than stealthy PEG‐based analogs due to the structure of phospholipid affinitive N‐oxides groups, which has attracted considerable attention to the synthesis of various zwitterionic copolymers with tertiary amine‐oxide grafts for enhanced anticancer drug delivery. However, poly(tertiary amine‐oxide)‐based amphiphilic copolymers with tumor intracellular microenvironment sensitivities, to the knowledge, have been rarely reported likely due to the lack of a controlled synthetic strategy. Herein, a reducible zwitterionic copolymer, poly(ε‐caprolactone)25‐SS‐poly(2‐(N‐oxide‐N,N‐diethylamino)ethyl methacrylate)30 (PCL25‐SS‐OPDEA30) is designed and synthesized successfully via combination of controlled polymerization techniques and post polymerization modification. Specifically, postoxidation of poly(tertiary amine) is confirmed to be a better synthetic strategy toward a well‐defined polymer structure relative to direct polymerization of N,N‐diethylaminoethyl methacrylate (ODEA). The effect of disulfide bridges on the self‐assembly behaviors, in vitro drug loading and drug release properties is investigated in detail. Notablely, the resulting micelles self‐assembled from PCL25‐SS‐OPDEA30 show much greater colloidal stability, higher drug loading content (DLC), and better in vitro tumor cell inhibition than the reduction‐insensitive counterparts. Overall, this study reports a robust strategy toward zwitterionic nanomedicines for on‐demand anticancer drug delivery. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10221352
Volume :
225
Issue :
4
Database :
Complementary Index
Journal :
Macromolecular Chemistry & Physics
Publication Type :
Academic Journal
Accession number :
175703829
Full Text :
https://doi.org/10.1002/macp.202300335