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Effects of non-invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in Parkinson's disease.
- Source :
- Frontiers in Aging Neuroscience; 2024, p1-13, 13p
- Publication Year :
- 2024
-
Abstract
- Non-invasive vagus nerve stimulation (nVNS) is an established neurostimulation therapy used in the treatment of epilepsy, migraine and cluster headache. In this randomized, double-blind, sham-controlled trial we explored the role of nVNS in the treatment of gait and other motor symptoms in Parkinson's disease (PD) patients. In a subgroup of patients, we measured selected neurotrophins, inflammatory markers and markers of oxidative stress in serum. Thirty-three PD patients with freezing of gait (FOG) were randomized to either active nVNS or sham nVNS. After baseline assessments, patients were instructed to deliver six 2 min stimulations (12 min/day) of the active nVNS/sham nVNS device for 1 month at home. Patients were then re-assessed. After a one-month washout period, they were allocated to the alternate treatment arm and the same process was followed. Significant improvements in key gait parameters (speed, stance time and step length) were observed with active nVNS. While serum tumor necrosis factor- a decreased, glutathione and brain-derived neurotrophic factor levels increased significantly (p < 0.05) after active nVNS treatment. Here we present the first evidence of the efficacy and safety of nVNS in the treatment of gait in PD patients, and propose that nVNS can be used as an adjunctive therapy in the management of PD patients, especially those suffering from FOG. [ABSTRACT FROM AUTHOR]
- Subjects :
- PARKINSON'S disease treatment
BIOMARKERS
EVALUATION of medical care
STATISTICS
VAGUS nerve
FISHER exact test
RANDOMIZED controlled trials
NEUROPSYCHOLOGICAL tests
NEUROINFLAMMATION
OXIDATIVE stress
PARKINSON'S disease
RESEARCH funding
DESCRIPTIVE statistics
QUESTIONNAIRES
BLIND experiment
DATA analysis software
DATA analysis
NEURAL stimulation
SYMPTOMS
Subjects
Details
- Language :
- English
- ISSN :
- 16634365
- Database :
- Complementary Index
- Journal :
- Frontiers in Aging Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 175690378
- Full Text :
- https://doi.org/10.3389/fnagi.2023.1331575