Back to Search
Start Over
Effect of Piascledine‐bacterial nanocellulose combination on experimental cutaneous wound healing in rat: Histopathological, biochemical and molecular studies.
- Source :
- International Wound Journal; Feb2024, Vol. 21 Issue 2, p1-15, 15p
- Publication Year :
- 2024
-
Abstract
- The study investigated the wound healing potential of Piascledine (an avocado/soybean mixture) alone and in combination with bacterial nanocellulose on rat cutaneous wounds. Full‐thickness excisional wounds (2 cm in diameter) were induced on the backs of 60 Sprague–Dawley rats, divided into four groups, treated with daily topical application of bacterial nanocellulose (BNC), Piascledine 10% (PSD 10%) and Piascledine+bacterial nanocellulose (PSD + BNC) (10 mg/disk) and normal saline (control) for 20 days. Wounds were monitored daily, and at 10, 20 and 30 days post‐injury (DPI), tissue samples were collected for biochemical, histopathological and molecular analyses. Treated rats with PSD and PSD + BNC showed a significant decrease in the wound area compared with other groups. PSD and particularly PSD + BNC modulated inflammation, improved fibroplasia and angiogenesis and scar tissue formation at short term. At the long term, they reduced the scar tissue size and improved collagen fibres alignment, tissue organization and remodelling as well as re‐epithelialization. PSD enhanced matrix metalloproteinase‐3 (MMP‐3) gene expression, collagen and glycosaminoglycans (GAGs) synthesis and decreased tissue inhibitor of metalloproteinase‐1 (TIMP‐1) gene expression at various stages of wound healing. The study concluded that topical application of Piascledine, particularly in combination with bacterial nanocellulose, promotes wound healing activity by modulating inflammation, regulating MMP‐3 expression and enhancing collagen and GAGs synthesis. [ABSTRACT FROM AUTHOR]
- Subjects :
- INFLAMMATION prevention
WOUND healing
STATISTICS
COLLAGEN
COMBINATION drug therapy
ANIMAL experimentation
ONE-way analysis of variance
NEOVASCULARIZATION
QUANTITATIVE research
TREATMENT effectiveness
RATS
CYTOCHEMISTRY
COMPARATIVE studies
GLYCOSAMINOGLYCANS
BIOMEDICAL materials
GENE expression
MATRIX metalloproteinases
SURGICAL site
ANTIMICROBIAL bandages
MESSENGER RNA
DESCRIPTIVE statistics
PROLINE
PLANT extracts
PHYTOSTEROLS
CUTANEOUS therapeutics
POLYMERASE chain reaction
DATA analysis software
DATA analysis
WOUND care
Subjects
Details
- Language :
- English
- ISSN :
- 17424801
- Volume :
- 21
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- International Wound Journal
- Publication Type :
- Academic Journal
- Accession number :
- 175669997
- Full Text :
- https://doi.org/10.1111/iwj.14418