Appearance of lentigines in an atopic dermatitis patient treated with dupilumab.

This article discusses a case of lentigines, or small hyperpigmented macules, that appeared on the wrists, hands, and knees of an 8-year-old girl with a history of atopic dermatitis. The lentigines developed after the patient started treatment with dupilumab, a medication used to treat atopic dermatitis. The article suggests that the inhibition of the IL-4 and IL-13 pathway by dupilumab may lead to an unregulated upregulation of melanogenesis, resulting in the formation of lentigines. The article emphasizes that lentigines are a rare and benign adverse event and reassures patients that they are not associated with an increased risk of skin cancer. [Extracted from the article]