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Identification of Novel -Glucosidase Inhibitors from Syzygium jambos (L.) Using Spectroscopy and Molecular Docking.
- Source :
- Plant Foods for Human Nutrition; Mar2024, Vol. 79 Issue 1, p73-82, 10p
- Publication Year :
- 2024
-
Abstract
- Fruits of Syzygium jambos (L.) are recognized as a "food", exhibiting significant antidiabetic activities. However, the α-glucosidase inhibition of the components from Syzygium jambos (L.) have not yet been investigated. In this study, a total of 14 compounds were isolated from Syzygium jambos (L.) Alston, eight of which showed significant inhibitory effects on α-glucosidase, with IC<subscript>50</subscript> values in the range of 0.011–0.665 mM. Notably, compounds 1–3 (IC<subscript>50</subscript>: 0.013, 0.011 and 0.030 mM, respectively) exhibited much stronger activity than acarbose (IC<subscript>50</subscript>: 2.329 ± 0.109 mM). The enzyme kinetics study indicated that compound 1 was an uncompetitive inhibitor, and compounds 2–8 were mixed-type inhibitors. Moreover, the interactions between compounds and α-glucosidase were investigated by molecular docking, which further revealed that the number of olefin double bonds and 2-COOH of heptadeca-phenols had a notable effect on the α-glucosidase inhibitory activity. This study demonstrated that Syzygium jambos (L.) fruit might serve as a functional food for the prevention of diabetes mellitus. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09219668
- Volume :
- 79
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Plant Foods for Human Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 175636225
- Full Text :
- https://doi.org/10.1007/s11130-023-01123-0