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13C MRI of hyperpolarized pyruvate at 120 µT.
- Source :
- Scientific Reports; 2/24/2024, Vol. 14 Issue 1, p1-7, 7p
- Publication Year :
- 2024
-
Abstract
- Nuclear spin hyperpolarization increases the sensitivity of magnetic resonance dramatically, enabling many new applications, including real-time metabolic imaging. Parahydrogen-based signal amplification by reversible exchange (SABRE) was employed to hyperpolarize [1-<superscript>13</superscript>C]pyruvate and demonstrate <superscript>13</superscript>C imaging in situ at 120 µT, about twice Earth's magnetic field, with two different signal amplification by reversible exchange variants: SABRE in shield enables alignment transfer to heteronuclei (SABRE-SHEATH), where hyperpolarization is transferred from parahydrogen to [1-<superscript>13</superscript>C]pyruvate at a magnetic field below 1 µT, and low-irradiation generates high tesla (LIGHT-SABRE), where hyperpolarization was prepared at 120 µT, avoiding magnetic field cycling. The 3-dimensional images of a phantom were obtained using a superconducting quantum interference device (SQUID) based magnetic field detector with submillimeter resolution. These <superscript>13</superscript>C images demonstrate the feasibility of low-field <superscript>13</superscript>C metabolic magnetic resonance imaging (MRI) of 50 mM [1-<superscript>13</superscript>C]pyruvate hyperpolarized by parahydrogen in reversible exchange imaged at about twice Earth's magnetic field. Using thermal <superscript>13</superscript>C polarization available at 120 µT, the same experiment would have taken about 300 billion years. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 14
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Scientific Reports
- Publication Type :
- Academic Journal
- Accession number :
- 175635823
- Full Text :
- https://doi.org/10.1038/s41598-024-54770-x