Tension-induced adhesion mode switching: the interplay between focal adhesions and clathrin-containing adhesion complexes.

A preprint abstract from biorxiv.org discusses the regulation and physiological implications of focal adhesion complexes (FAs) and clathrin-containing adhesion complexes (CCACs) in a breast cancer model. The study found that FAs and CCACs are mutually exclusive and inversely regulated complexes, with their association influenced by plasma membrane tension and actomyosin contractility. Increased membrane tension promotes the association of CCACs, leading to decreased cancer cell proliferation, spreading, and migration, while lower membrane tension promotes the formation of FAs, potentially facilitating cancer progression. The research provides insights into the biomechanical regulation of CCACs and FAs and their contrasting roles in modulating cancer cell progression. [Extracted from the article]