PP2A catalytic subunit alpha is critically required for CD8+ T cell homeostasis and anti-bacterial responses.

According to a preprint abstract from biorxiv.org, the role of serine/threonine phosphatases in T cell biology is not well understood. The study focused on protein phosphatase 2A (PP2A), which is abundantly expressed in T cells. By deleting the catalytic subunit alpha isoform of PP2A in T cells, the researchers found that it is crucial for the homeostasis and effector functions of CD8+ T cells. PP2A deficiency led to reduced proliferation, survival, and impaired anti-bacterial responses in CD8+ T cells. The study also identified potential targets of PP2A, such as mTORC1 and AKT. It is important to note that this preprint has not yet undergone peer review. [Extracted from the article]