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Involvement and repair of epithelial barrier dysfunction in allergic diseases.

Authors :
Hui-Fei Lu
Yi-Chi Zhou
Li-Tao Yang
Qian Zhou
Xi-Jia Wang
Shu-Qi Qiu
Bao-Hui Cheng
Xian-Hai Zeng
Source :
Frontiers in Immunology; 2024, p1-15, 15p
Publication Year :
2024

Abstract

The epithelial barrier serves as a critical defense mechanism separating the human body fromthe external environment, fulfilling both physical and immune functions. This barrier plays a pivotal role in shielding the body from environmental risk factors such as allergens, pathogens, and pollutants. However, since the 19th century, the escalating threats posed by environmental pollution, global warming, heightened usage of industrial chemical products, and alterations in biodiversity have contributed to a noteworthy surge in allergic disease incidences. Notably, allergic diseases frequently exhibit dysfunction in the epithelial barrier. The proposed epithelial barrier hypothesis introduces a novel avenue for the prevention and treatment of allergic diseases. Despite increased attention to the role of barrier dysfunction in allergic disease development, numerous questions persist regarding the mechanisms underlying the disruption of normal barrier function. Consequently, this review aims to provide a comprehensive overview of the epithelial barrier's role in allergic diseases, encompassing influencing factors, assessment techniques, and repair methodologies. By doing so, it seeks to present innovative strategies for the prevention and treatment of allergic diseases. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16643224
Database :
Complementary Index
Journal :
Frontiers in Immunology
Publication Type :
Academic Journal
Accession number :
175588053
Full Text :
https://doi.org/10.3389/fimmu.2024.1348272