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Involvement and repair of epithelial barrier dysfunction in allergic diseases.
- Source :
- Frontiers in Immunology; 2024, p1-15, 15p
- Publication Year :
- 2024
-
Abstract
- The epithelial barrier serves as a critical defense mechanism separating the human body fromthe external environment, fulfilling both physical and immune functions. This barrier plays a pivotal role in shielding the body from environmental risk factors such as allergens, pathogens, and pollutants. However, since the 19th century, the escalating threats posed by environmental pollution, global warming, heightened usage of industrial chemical products, and alterations in biodiversity have contributed to a noteworthy surge in allergic disease incidences. Notably, allergic diseases frequently exhibit dysfunction in the epithelial barrier. The proposed epithelial barrier hypothesis introduces a novel avenue for the prevention and treatment of allergic diseases. Despite increased attention to the role of barrier dysfunction in allergic disease development, numerous questions persist regarding the mechanisms underlying the disruption of normal barrier function. Consequently, this review aims to provide a comprehensive overview of the epithelial barrier's role in allergic diseases, encompassing influencing factors, assessment techniques, and repair methodologies. By doing so, it seeks to present innovative strategies for the prevention and treatment of allergic diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALLERGIES
INDUSTRIAL goods
GLOBAL warming
POLLUTION
DISEASE incidence
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Database :
- Complementary Index
- Journal :
- Frontiers in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 175588053
- Full Text :
- https://doi.org/10.3389/fimmu.2024.1348272