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Elevated soluble LOX-1 predicts risk of first-time myocardial infarction.

Authors :
Schiopu, Alexandru
Björkbacka, Harry
Narasimhan, Gayathri
Loong, Bi Juin
Engström, Gunnar
Melander, Olle
Orho-Melander, Marju
Nilsson, Jan
Source :
Annals of Medicine; 2023, Vol. 55 Issue 2, p1-10, 10p
Publication Year :
2023

Abstract

There is an unmet clinical need for novel therapies addressing the residual risk in patients receiving guideline preventive therapy for coronary heart disease. Experimental studies have identified a pro-atherogenic role of the oxidized LDL receptor LOX-1. We investigated the association between circulating soluble LOX-1 (sLOX-1) and the risk for development of myocardial infarction. The study subjects (n = 4658) were part of the Malmö Diet and Cancer study. The baseline investigation was carried out 1991-1994 and the incidence of cardiovascular events monitored through national registers during a of 19.5 ± 4.9 years follow-up. sLOX-1 and other biomarkers were analyzed by proximity extension assay and ELISA in baseline plasma. Subjects in the highest tertile of sLOX-1 had an increased risk of myocardial infarction (hazard ratio (95% CI) 1.76 (1.40-2.21) as compared with those in the lowest tertile. The presence of cardiovascular risk factors was related to elevated sLOX-1, but the association between sLOX-1 and risk of myocardial infarction remained significant when adjusting for risk factors. In this prospective population study we found an association between elevated sLOX-1, the presence of carotid disease and the risk for first-time myocardial infarction. Taken together with previous experimental findings of a pro-atherogenic role of LOX-1, this observation supports LOX-1 inhibition as a possible target for prevention of myocardial infarction. Activation of the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) represents a possible target for treatment of the residual inflammatory risk in cardiovascular patients on guideline therapy. Having high levels of soluble LOX-1, a marker of cellular LOX-1 activation, is associated with an increased risk for development of myocardial infarction and heart failure. sLOX-1 levels correlated with major cardiovascular risk factors and biomarkers reflecting LDL oxidation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
07853890
Volume :
55
Issue :
2
Database :
Complementary Index
Journal :
Annals of Medicine
Publication Type :
Academic Journal
Accession number :
175571461
Full Text :
https://doi.org/10.1080/07853890.2023.2296552