D−− phenotype caused by a novel RHCE null allele.

This article discusses a rare blood phenotype known as D−−, which is characterized by the absence of RhCE antigens on red blood cells (RBCs) and often accompanied by increased D antigen expression. The study analyzes a blood sample from an Argentinean patient with the D−− phenotype and investigates the serologic and molecular aspects of the condition. The results reveal a new hybrid RHCE null allele, designated as RHCE*01N.16, which is responsible for the D−− phenotype and exhibits enhanced D antigen expression. This finding is considered unusual in all populations. The study was supported by grants from the Agencia Nacional de Promoción Científica y Tecnológica and Universidad Nacional de Rosario in Argentina. [Extracted from the article]