Findings from Mashhad University of Medical Sciences Yields New Findings on Ulcers (Relation Between Tissue Iron Content and Polarization of Macrophages In Diabetic Ulcer and the Transitional Zone of Diabetic Ulcers With Major Amputation).

A study conducted by researchers at Mashhad University of Medical Sciences in Iran explored the relationship between tissue iron levels and the polarization of macrophages in diabetic ulcers. The researchers found that the ratio of M2 to M1 macrophages was decreased in ulcer tissue compared to the transitional zone of diabetic ulcers. Additionally, the expression of angiogenesis-related genes was increased in ulcer tissue, while the expression of vascular stability-related genes was decreased. The study did not find a connection between tissue iron and the polarization of macrophages. This research provides insights into the development of chronic diabetes complications and may contribute to future treatment strategies. [Extracted from the article]