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Evidence for the Clinical Association between Demodex and Rosacea: A Review.

Evidence for the Clinical Association between Demodex and Rosacea: A Review.

Authors :
Wei, Fen
Li, Li
Kong, Yi
Yan, Xiaofeng
Varghese, Kevin J.
Zhang, Song
Jiang, Jian
Chai, Bao
Chen, Hongxiang
Source :
Dermatology (10188665); 2024, Vol. 240 Issue 1, p95-102, 8p
Publication Year :
2024

Abstract

Background: Rosacea is a chronic inflammatory dermatological condition in humans, and its pathogenesis remains unclear. However, the development of rosacea is suspected to be related to Demodex, a microscopic commensal organism that resides in or near hair follicles and sebaceous glands. Although Demodex is known to be a host-specific, obligate commensal organism, it is currently difficult to be cultured in vitro to parasitize and infect other animal hosts. Therefore, direct evidence for a pathogenic role of Demodex in rosacea is currently lacking. Summary: As circumstantial evidence, non-invasive skin-detecting techniques have shown abnormally elevated numbers of Demodex in rosacea patients. Increased cytokine levels such as IL-10, IL-8, and IL-12p70 have been observed in human sebocytes following the Demodex challenge, and acaricides have been found to be effective in rosacea therapy, all point to a close relationship between Demodex and rosacea. Based on these findings, we conducted a comprehensive literature review to summarize the current state of knowledge, research insights, and clinical treatment recommendations for Demodex-associated rosacea, with the ultimate goal of improving patient outcomes. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10188665
Volume :
240
Issue :
1
Database :
Complementary Index
Journal :
Dermatology (10188665)
Publication Type :
Academic Journal
Accession number :
175459536
Full Text :
https://doi.org/10.1159/000534245