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Evidence for the Clinical Association between Demodex and Rosacea: A Review.
Evidence for the Clinical Association between Demodex and Rosacea: A Review.
- Source :
- Dermatology (10188665); 2024, Vol. 240 Issue 1, p95-102, 8p
- Publication Year :
- 2024
-
Abstract
- Background: Rosacea is a chronic inflammatory dermatological condition in humans, and its pathogenesis remains unclear. However, the development of rosacea is suspected to be related to Demodex, a microscopic commensal organism that resides in or near hair follicles and sebaceous glands. Although Demodex is known to be a host-specific, obligate commensal organism, it is currently difficult to be cultured in vitro to parasitize and infect other animal hosts. Therefore, direct evidence for a pathogenic role of Demodex in rosacea is currently lacking. Summary: As circumstantial evidence, non-invasive skin-detecting techniques have shown abnormally elevated numbers of Demodex in rosacea patients. Increased cytokine levels such as IL-10, IL-8, and IL-12p70 have been observed in human sebocytes following the Demodex challenge, and acaricides have been found to be effective in rosacea therapy, all point to a close relationship between Demodex and rosacea. Based on these findings, we conducted a comprehensive literature review to summarize the current state of knowledge, research insights, and clinical treatment recommendations for Demodex-associated rosacea, with the ultimate goal of improving patient outcomes. [ABSTRACT FROM AUTHOR]
- Subjects :
- ROSACEA
DEMODEX
LITERATURE reviews
SEBACEOUS glands
HAIR follicles
MICROORGANISMS
Subjects
Details
- Language :
- English
- ISSN :
- 10188665
- Volume :
- 240
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Dermatology (10188665)
- Publication Type :
- Academic Journal
- Accession number :
- 175459536
- Full Text :
- https://doi.org/10.1159/000534245