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Effects of sodium ferulate for injection on anticoagulation of warfarin in rats in vivo.
- Source :
- BMC Complementary Medicine & Therapies; 2/14/2024, Vol. 24 Issue 1, p1-12, 12p
- Publication Year :
- 2024
-
Abstract
- Background: Herb-drug interactions may result in increased adverse drug reactions or diminished drug efficacy, especially for drugs with a narrow therapeutic index such as warfarin. The current study investigates the effects of sodium ferulate for injection (SFI) on anticoagulation of warfarin from aspects of pharmacodynamics and pharmacokinetics in rats and predicts the risk of the combination use. Methods: Rats were randomly divided into different groups and administered single- or multiple-dose of warfarin (0.2 mg/kg) with or without SFI of low dose (8.93 mg/kg) or high dose (26.79 mg/kg). Prothrombin time (PT) and activated partial thromboplastin time (APTT) were detected by a blood coagulation analyzer, and international normalized ratio (INR) values were calculated. UPLC-MS/MS was conducted to measure concentrations of warfarin enantiomers and pharmacokinetic parameters were calculated by DAS2.0 software. Results: The single-dose study demonstrated that SFI alone had no effect on coagulation indices, but significantly decreased PT and INR values of warfarin when the two drugs were co-administered (P < 0.05 or P < 0.01), while APTT values unaffected (P > 0.05). C<subscript>max</subscript> and AUC of R/S-warfarin decreased but CL increased significantly in presence of SFI (P < 0.01). The multiple-dose study showed that PT, APTT, INR, and concentrations of R/S-warfarin decreased significantly when SFI was co-administered with warfarin (P < 0.01). Warfarin plasma protein binding rate was not significantly changed by SFI (P > 0.05). Conclusions: The present study implied that SFI could accelerate warfarin metabolism and weaken its anticoagulation intensity in rats. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROTHROMBIN time
PARTIAL thromboplastin time
COMPUTER software
INJECTIONS
COMBINATION drug therapy
IN vivo studies
DRUG-herb interactions
GASTRIC intubation
BLOOD proteins
WARFARIN
ANIMAL experimentation
LIQUID chromatography-mass spectrometry
AUTOANALYZERS
BLOOD coagulation
INTRAPERITONEAL injections
RISK assessment
RATS
T-test (Statistics)
DESCRIPTIVE statistics
RESEARCH funding
INTERNATIONAL normalized ratio
RECEIVER operating characteristic curves
DATA analysis software
CARBOCYCLIC acids
PHYSIOLOGIC salines
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 26627671
- Volume :
- 24
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Complementary Medicine & Therapies
- Publication Type :
- Academic Journal
- Accession number :
- 175458397
- Full Text :
- https://doi.org/10.1186/s12906-024-04389-2