Cohort Profile: The Shanghai Maternal-Child Pairs Cohort (MCPC).

The Shanghai Maternal-Child Pairs Cohort (MCPC) is a study conducted in Shanghai, China, that examines the impact of psychological factors and environmental exposure on childhood disorders. The cohort consists of 5507 mothers and their children, who are closely followed throughout pregnancy and early childhood. The study collects data on demographics, environmental exposures, maternal stress, social support, behavioral lifestyles, neurocognitive development, and biological samples. The study provides valuable insights into maternal and child health in Shanghai and aims to improve the physical and mental health of mothers and children in China. The study found that environmental pollutants, penicillin exposure, and PFAS exposure had adverse effects on fetal growth and neurocognitive development. Maternal emotional stress and positive lifestyles had positive effects on pregnancy health and children's development. The study has strengths in its comprehensive follow-up visits and sample collection, but limitations in participant representation and lack of biological samples from fathers and children. More information can be found on the Shanghai MCPC study website. [Extracted from the article]