Back to Search
Start Over
CD8+ Trms against malaria liver-stage: prospects and challenges.
- Source :
- Frontiers in Immunology; 2024, p1-10, 10p
- Publication Year :
- 2024
-
Abstract
- Attenuated sporozoites provide a valuable model for exploring protective immunity against the malarial liver stage, guiding the design of highly efficient vaccines to prevent malaria infection. Liver tissue-resident CD<superscript>8+</superscript> T cells (CD<superscript>8+</superscript> Trm cells) are considered the host front-line defense against malaria and are crucial to developing prime-trap/target strategies for pre-erythrocytic stage vaccine immunization. However, the spatiotemporal regulatory mechanism of the generation of liver CD<superscript>8+</superscript> Trm cells and their responses to sporozoite challenge, as well as the protective antigens they recognize remain largely unknown. Here, we discuss the knowledge gap regarding liver CD<superscript>8+</superscript> Trm cell formation and the potential strategies to identify predominant protective antigens expressed in the exoerythrocytic stage, which is essential for highefficacy malaria subunit pre-erythrocytic vaccine designation. [ABSTRACT FROM AUTHOR]
- Subjects :
- MALARIA
T cells
MALARIA vaccines
SPOROZOITES
LIVER
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Database :
- Complementary Index
- Journal :
- Frontiers in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 175319526
- Full Text :
- https://doi.org/10.3389/fimmu.2024.1344941