Біомеханічні параметри розвитку втомлювальних процесів у muscle gastrocnemius щурів за хронічної алкоголізації та застосування водорозчинних С60-фуллеренів.

Biomechanical changes in the contraction of the muscle gastrocnemius of rats after chronic alcoholization for 3, 6, and 9 months are studied. Oral consumption of water-soluble C60 fullerenes at a dose of 1 mg.kg^-1 is used as a corrective agent throughout the experiment. Administration of the drug in the experimental groups is carried out in three ways: 1 h before drinking alcohol, together with alcohol, and 1 h after drinking alcohol. It is established that the usage of water-soluble C60 fullerenes reduces the time of fatigue processes in alcoholised muscle by 11–39% and is most effective in the long-term development of alcoholic myopathy. The positive effect of the drug in the therapeutic regimen of usage (together with alcohol) exceeded by 6–10% its effect in prophylactic (1 h before alcohol consumption) and therapeutic (1 h after alcohol consumption) regimens, the difference in effects between which is not observed. [ABSTRACT FROM AUTHOR]