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The effect of haloperidol's perioperative application on postoperative delirium in elderly patients: a systematic review and meta-analysis.
- Source :
- BMC Anesthesiology; 2/7/2024, Vol. 24 Issue 1, p1-10, 10p
- Publication Year :
- 2024
-
Abstract
- Objectives: To systematically review the evidence about the effect of haloperidol on postoperative delirium in elderly patients. Methods: PubMed, Embase, the Cochrane Library and China National Knowledge Infrastructure were used to find concerned studies for meta-analysis. The main outcome was the incidence of postoperative delirium, and the secondary outcomes were side effects of haloperidol and the length of hospital stay. The meta-analyses were conducted using the Review Manager Version 5.1. This study was conducted based on the PRISMA statement. Results: Eight RCTs (1569 patients) were included in the meta-analysis. There was a significant difference in the incidence of postoperative delirium between haloperidol and control groups (OR = 0.62, 95%CI 0.48–0.80, P = 0.0002, I<superscript>2</superscript> = 20%). In addition, side effects of haloperidol and the duration of hospitalization were comparable (OR = 0.58, 95%CI 0.25–1.35, P = 0.21, I<superscript>2</superscript> = 0%; MD =-0.01, 95%CI -0.16-0.15, P = 0.92, I<superscript>2</superscript> = 28%). Subgroup analysis implied the effect of haloperidol on postoperative delirium might vary with the dose (5 mg daily: OR = 0.40, 95%CI 0.22–0.71, P = 0.002, I<superscript>2</superscript> = 0%; <5 mg daily: OR = 0.72, 95%CI 0.42–1.23, P = 0.23, I<superscript>2</superscript> = 0%). Conclusions: The meta-analysis revealed perioperative application of haloperidol could decrease the occurrence of postoperative delirium without obvious side effects in elderly people, and high-dose haloperidol (5 mg daily) possessed a greater positive effect. [ABSTRACT FROM AUTHOR]
- Subjects :
- PREVENTION of surgical complications
PERIOPERATIVE care
ONLINE information services
MEDICAL databases
META-analysis
MEDICAL information storage & retrieval systems
CONFIDENCE intervals
HALOPERIDOL
TREATMENT effectiveness
DELIRIUM
DESCRIPTIVE statistics
DATA analysis software
MEDLINE
ODDS ratio
OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 14712253
- Volume :
- 24
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Anesthesiology
- Publication Type :
- Academic Journal
- Accession number :
- 175276212
- Full Text :
- https://doi.org/10.1186/s12871-024-02434-8