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Deep dermatophytosis caused by Trichophyton rubrum in an elderly patient with CARD9 deficiency: A case report and literature review.

Authors :
Ansai, Osamu
Hayashi, Ryota
Nakamura, Anna
Sasaki, Jin
Hasegawa, Akito
Deguchi, Tokiko
Yuki, Akihiko
Oike, Naoki
Ariizumi, Takashi
Abe, Masahiro
Miyazaki, Yoshitsugu
Takenouchi, Tatsuya
Kawashima, Hiroyuki
Abe, Riichiro
Source :
Journal of Dermatology; Feb2024, Vol. 51 Issue 2, p294-300, 7p
Publication Year :
2024

Abstract

Deep dermatophytosis is an invasive and sometimes life‐threatening fungal infection mainly reported in immunocompromised patients. However, a caspase recruitment domain‐containing protein 9 (CARD9) deficiency has recently been reported to cause deep dermatophytosis. Herein, we report the first Japanese case of deep dermatophytosis associated with CARD9 deficiency. An 80‐year‐old Japanese man with tinea corporis presented with subcutaneous nodules on his left sole. Histopathological findings revealed marked epithelioid cell granulomas with filamentous fungal structures in the deep dermis and subcutis, and the patient was diagnosed with deep dermatophytosis. Despite antifungal therapy, the subcutaneous nodule on his left sole gradually enlarged, his left calcaneal bone was invaded, and the patient finally underwent amputation of his left leg. Genetic analysis revealed a homozygous CARD9 c.586 A > G (p. Lys196Glu) variant, suggesting a CARD9 deficiency. Here, we discuss the clinical features of CARD9 deficiency–associated deep dermatophytosis with a case report and review of the literature. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03852407
Volume :
51
Issue :
2
Database :
Complementary Index
Journal :
Journal of Dermatology
Publication Type :
Academic Journal
Accession number :
175229433
Full Text :
https://doi.org/10.1111/1346-8138.16995