Single-domain antibodies reveal unique borreliacidal epitopes on the Lyme disease vaccine antigen, Outer surface protein A (OspA).

A recent preprint abstract discusses the use of single-domain antibodies, derived from camels, to study the antigenic landscape of the Lyme disease vaccine antigen, Outer surface protein A (OspA). The researchers generated a library of these antibodies and identified 21 unique antibodies that targeted two epitope bins on OspA. Further analysis revealed that six of these antibodies had functional properties associated with protective human monoclonal antibodies, including borreliacidal activity. The study also found that the antibodies reacted differently with the seven OspA serotypes associated with Borrelia burgdorferi genospecies, suggesting the presence of conserved epitopes across serotypes. This research has not yet undergone peer review. [Extracted from the article]