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Benefits of resistance training are not preserved after cessation of supervised training in prostate cancer patients on androgen deprivation therapy.
- Source :
- European Journal of Sport Science; Jan2024, Vol. 24 Issue 1, p116-126, 11p
- Publication Year :
- 2024
-
Abstract
- Resistance exercise training is effective to counteract the adverse effects of androgen deprivation therapy (ADT) on body composition, muscle mass and leg strength in prostate cancer patients (PCa). However, it is unknown whether these effects can be autonomously maintained after cessation of the supervised program. Sixty‐eight PCa patients on ADT were included. The exercise intervention group (EX, n = 37) performed 20 weeks of supervised resistance exercise training. Thereafter, patients were advised to autonomously continue exercise training. The control group (CON, n = 31) only received usual care. Outcome measures were compared between baseline and after 1 year. Changes during the intervention (baseline vs. 20 weeks) and follow‐up period (20 weeks vs. 1 year) were descriptively explored. In EX, 83% reported to have continued exercise training themselves. After 1 year, fat mass gains were attenuated in EX compared to CON (1.2 ± 2.6 and 2.8 ± 1.9 kg, respectively; time × treatment effect p = 0.032). The fat percentage increased, and lean mass and quadriceps muscle cross‐sectional area decreased over time, with no differences between groups (overall 1.6 ± 2.1%, −0.7 ± 2.3 kg and −2.2 ± 2.9 cm2, respectively; time effects, all p < 0.05). For muscle strength, an increase of ∼5% in EX was observed, significantly different from the ∼10% decrease in CON (p < 0.001). Subsequent analyses showed that the initial exercise training‐obtained gains in lean mass, muscle mass and strength in EX compared to CON, declined during the follow‐up period. In conclusion, PCa patients on ADT are not capable to autonomously maintain the exercise‐obtained gains of a 20‐week supervised training program over a subsequent 1‐year period. Highlights: ADT for prostate cancer results in many side effects, including muscle mass lossA supervised resistance exercise training program can counteract many side effectsAfter cessation of the supervised program, exercise benefits are not effectively preservedMore focus on sustainability of exercise programs during ADT is required [ABSTRACT FROM AUTHOR]
- Subjects :
- RESISTANCE training
BODY composition
RESEARCH
DIGITAL image processing
ANTIANDROGENS
HORMONE therapy
EVALUATION of human services programs
SKELETAL muscle
PHOTON absorptiometry
ANALYSIS of variance
ANTHROPOMETRY
CANCER patients
RANDOMIZED controlled trials
COMPARATIVE studies
ACCELEROMETRY
T-test (Statistics)
SEVERITY of illness index
PHYSICAL activity
MUSCLE strength
RESEARCH funding
DESCRIPTIVE statistics
QUADRICEPS muscle
REPEATED measures design
CHI-squared test
WAIST circumference
BONE metastasis
EXERCISE intensity
STATISTICAL sampling
COMPUTED tomography
DATA analysis software
BODY mass index
PROSTATE tumors
LONGITUDINAL method
COMORBIDITY
Subjects
Details
- Language :
- English
- ISSN :
- 17461391
- Volume :
- 24
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- European Journal of Sport Science
- Publication Type :
- Academic Journal
- Accession number :
- 175141012
- Full Text :
- https://doi.org/10.1002/ejsc.12050