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A Text Mining Approach to Explore IFNε Literature and Biological Mechanisms.
- Source :
- Medinfo; 2023, Vol. 310, p1036-1040, 5p
- Publication Year :
- 2023
-
Abstract
- Interferons (IFN) constitute a primary line of protection against mucosal infection, with IFN research spanning over 60 years and encompassing a vast everexpanding amount of literature. Most of what is currently understood has been derived from extensive research defining the roles of "classical" type I IFNs, IFNα and IFNβ. However, little is known regarding responses elicited by less wellcharacterized IFN subtypes such as IFNε. In this paper, we combined a deductive text mining analysis of IFNε literature characterizing literature-derived knowledge with a comparative analysis of other type I and type III IFNs. Utilizing these approaches, three clusters of terms were extracted from the literature covering different aspects of IFNε research and a set of 47 genes uniquely cited in the context of IFNε. The use of these "in silico" approaches support the expansion of current understanding and the creation of new knowledge surrounding IFNε. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of interferons
COMPUTER simulation
COMPUTER software
CONFERENCES & conventions
METABOLISM
INTERFERONS
COMPARATIVE studies
BIOINFORMATICS
CELLULAR signal transduction
GENES
INFORMATION retrieval
AUTOMATION
DESCRIPTIVE statistics
CLUSTER analysis (Statistics)
DATA analysis software
DATA mining
MEDICAL research
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 15696332
- Volume :
- 310
- Database :
- Complementary Index
- Journal :
- Medinfo
- Publication Type :
- Conference
- Accession number :
- 175124615
- Full Text :
- https://doi.org/10.3233/SHTI231122