Back to Search Start Over

The Population-Attributable Fractions of Small-for-Gestational-Age Births: Results from the Japan Birth Cohort Consortium.

Authors :
Ishitsuka, Kazue
Piedvache, Aurélie
Kobayashi, Sumitaka
Iwama, Noriyuki
Nishimura, Tomoko
Watanabe, Masahiro
Metoki, Hirohito
Iwata, Hiroyoshi
Miyashita, Chihiro
Ishikuro, Mami
Obara, Taku
Sakurai, Kenichi
Rahman, Mohammad Shafiur
Tanaka, Keiko
Miyake, Yoshihiro
Horikawa, Reiko
Kishi, Reiko
Tsuchiya, Kenji J.
Mori, Chisato
Kuriyama, Shinichi
Source :
Nutrients; Jan2024, Vol. 16 Issue 2, p186, 12p
Publication Year :
2024

Abstract

A fetal growth restriction is related to adverse child outcomes. We investigated risk ratios and population-attributable fractions (PAF) of small-for-gestational-age (SGA) infants in the Japanese population. Among 28,838 infants from five ongoing prospective birth cohort studies under the Japan Birth Cohort Consortium, two-stage individual-participant data meta-analyses were conducted to calculate risk ratios and PAFs for SGA in advanced maternal age, pre-pregnancy underweight, and smoking and alcohol consumption during pregnancy. Risk ratio was calculated using modified Poisson analyses with robust variance and PAF was calculated in each cohort, following common analyses protocols. Then, results from each cohort study were combined by meta-analyses using random-effects models to obtain the overall estimate for the Japanese population. In this meta-analysis, an increased risk (risk ratio, [95% confidence interval of SGA]) was significantly associated with pre-pregnancy underweight (1.72 [1.42–2.09]), gestational weight gain (1.95 [1.61–2.38]), and continued smoking during pregnancy (1.59 [1.01–2.50]). PAF of underweight, inadequate gestational weight gain, and continued smoking during pregnancy was 10.0% [4.6–15.1%], 31.4% [22.1–39.6%], and 3.2% [−4.8–10.5%], respectively. In conclusion, maternal weight status was a major contributor to SGA births in Japan. Improving maternal weight status should be prioritized to prevent fetal growth restriction. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20726643
Volume :
16
Issue :
2
Database :
Complementary Index
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
175077313
Full Text :
https://doi.org/10.3390/nu16020186