Linear deposits of IgM along the dermo‐epidermal junction possibly associated with non‐classical clinical features in bullous pemphigoid.

This article discusses a case of bullous pemphigoid (BP), a skin disorder characterized by blistering and erosions. The standard diagnostic method for BP involves the detection of IgG autoantibodies and/or C3 complement fraction at the dermo-epidermal junction (DEJ). However, this particular case presented with linear deposits of IgM at the DEJ, along with non-classical clinical features. The significance of IgM in cutaneous immunopathology is not well understood, and the existence of IgM-mediated BP has been a topic of debate. The patient was treated with oral corticosteroids and eventually achieved complete clinical remission. [Extracted from the article]