Back to Search Start Over

Mice Generated with Induced Pluripotent Stem Cells Derived from Mucosal-Associated Invariant T Cells.

Authors :
Sugimoto, Chie
Fujita, Hiroyoshi
Wakao, Hiroshi
Source :
Biomedicines; Jan2024, Vol. 12 Issue 1, p137, 20p
Publication Year :
2024

Abstract

The function of mucosal-associated invariant T (MAIT) cells, a burgeoning member of innate-like T cells abundant in humans and implicated in many diseases, remains obscure. To explore this, mice with a rearranged T cell receptor (TCR) α or β locus, specific for MAIT cells, were generated via induced pluripotent stem cells derived from MAIT cells and were designated Vα19 and Vβ8 mice, respectively. Both groups of mice expressed large numbers of MAIT cells. The MAIT cells from these mice were activated by cytokines and an agonist to produce IFN-γ and IL-17. While Vβ8 mice showed resistance in a cancer metastasis model, Vα19 mice did not. Adoptive transfer of MAIT cells from the latter into the control mice, however, recapitulated the resistance. These mice present an implication for understanding the role of MAIT cells in health and disease and in developing treatments for the plethora of diseases in which MAIT cells are implicated. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22279059
Volume :
12
Issue :
1
Database :
Complementary Index
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
175047715
Full Text :
https://doi.org/10.3390/biomedicines12010137